Methionine metabolism in human pregnancy

摘要: Background: Hyperhomocysteinemia during pregnancy, which is a consequence of perturbations in methionine and/or folate metabolism, has been implicated adverse outcomes such as neural tube defects, preeclampsia, spontaneous abortion, and premature delivery. The adaptive changes metabolism pregnancy humans have not determined. Objective: Our objective was to examine the kinetics its rate transsulfuration transmethylation healthy women with advancing gestation. Design: whole-body appearance (Ra) phenylalanine measured pregnant first (n ¼ 10), second 5), third 10) trimesters pregnancy. These data were compared those for nonpregnant 8). Tracers [1- 13 C]methionine, [C 2 H3]methionine, [ H5]phenylalanine administered prime-constant infusions. effect enteral high-protein, mixed-nutrient load on tracer-determined variables also examined. Results: In women, Ra significantly (P , 0.05) lower trimester than that women. A linear positive correlation evident between gestational age Ra. fractional total higher trimester, whereas trimester. Plasma concentrations cysteine homocysteine Conclusions: Uncomplicated associated early gestation late may implications understanding role complications nutritional care Am J Clin Nutr 2010;91:357‐65.