Cancer Therapy and Dendritic Cell Immunomodulation

摘要: Conventional cancer treatment still uses three important modalities of the last four decades: surgery, radiotherapy, and cytotoxic chemotherapy. For metastatic disease, chemotherapy is mainstay treatment, although it broadly targeted results in toxicity to normal tissues with limited expectation curing tumors. Immunotherapies have also been explored over several decades. Among immunotherapies, approaches based on dendritic cell vaccines are particularly promising, since cells, as professional antigen-presenting can utilize apoptosis/necrosis-induced therapy tumors elicit improved antitumor immunity through acquisition tumor antigens from dying cells. The combination conventional vaccine one induce protective therapeutic efficacy against cancer. However, impacting endogenous exogenous activities commonly associated myelosuppression. New strategies necessary develop feasible effective combinatorial for treatment. We recently shown that short-term non-toxic low-dose chemotherapy, so-called chemomodulation, prior intralesional injection targets multiple immunological stromal elements environment, opening a new opportunity