Electrospun biphasic drug release polyvinylpyrrolidone/ethyl cellulose core/sheath nanofibers.

摘要: Abstract The capability of core/sheath nanofibers prepared using coaxial electrospinning to provide adjustable biphasic drug release was investigated. Using ketoprofen (KET) as the model drug, polyvinylpyrrolidone sheath polymer, and ethyl cellulose core matrix, process could be conducted smoothly continuously without spinneret clogging. Scanning electron microscopy transmission revealed linear with homogeneous clear structures. Differential scanning calorimetry X-ray diffraction verified that were nanocomposites, present in polymer matrix an amorphous state. Attenuated total reflectance–Fourier transform infrared spectra demonstrated compatible KET owing hydrogen bonding. In vitro dissolution tests showed typical profiles consisting immediate sustained release. amount released first phase tailored by adjusting flow rate, remaining second controlled a diffusion mechanism. study shows simple useful approach for systematic design fabrication novel biomaterials structural characteristics providing complicated programmed electrospinning.