The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients
作者： Joana Maira Valentini Zacarias , Emília Ângela Sippert , Patrícia Yumeko Tsuneto , Jeane Eliete Laguila Visentainer , Cléverson de Oliveira e Silva
DOI: 10.1155/2015/147056
关键词:
摘要: A case-control study was conducted on patients with chronic periodontitis (CP) and healthy controls the aim of evaluating possible association between interleukin 17A (IL17A) G197A (rs2275913) IL17F T7488C (rs763780) polymorphisms periodontitis. Genotypes were determined by PCR-RFLP method. Statistical analyses using OpenEpi SNPStas software to calculate Chi-square Yates correction or Fisher's exact tests, odds ratios (OR), 95% confidence intervals (CIs). used Hardy-Weinberg equilibrium. IL17A AA genotype more frequent in codominant recessive models (P = 0.09; OR 2.53 P 0.03; 2.46, resp.), females CP 0.01, 4.34), Caucasoid 3.45), nonsmoking Caucasian 0.04, 3.51). The allele also Caucasians 1.59). polymorphism not associated In these from Southern Brazil, rs2275913 polymorphisms, genotype, a susceptibility
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