Polyamide nucleic acid derivatives, and agents, and processes for preparing them

作者: Gerhard Breipohl , David William Will , Eugen Uhlmann

DOI:

关键词:

摘要: The present invention relates to PNA derivatives which carry, at the C terminus, or both and N termini of backbone, one more phosphoryl radicals. radicals where appropriate, labeling groups, groups for crosslinking, promote intracellular uptake, increase binding affinity derivative nucleic acids. furthermore a process preparing above-mentioned their use as pharmaceuticals diagnostic agents.

参考文章(46)
Kelly Sprankle, Muthiah Manoharan, Ole Buchardt, Michael Egholm, Peter Nielsen, Michael Griffith, John Kiely, Jesper Lohse, Soren Holst Sonnichsen, Peptide nucleic acid conjugates ,(1995)
Gemma Tarrasón, David Bellido, Ramon Eritja, Senén Vilaró, Jaume Piulats, Intracellular distribution of digoxigenin-labeled phosphorothioate oligonucleotides. Methods in Enzymology. ,vol. 313, pp. 257- 268 ,(2000) , 10.1016/S0076-6879(00)13016-2
Muthiah Manoharan, Phillip Dan Cook, 2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides ,(1998)
Alfonso R. Gennaro, Joseph P. Remington, Remington's pharmaceutical sciences Published in <b>1975</b> in Easton Pa) by Mack. ,(1985)
Holger Wallmeier, Eugen Uhlmann, Gerhard Breipohl, Anuschirwan Peyman, Phosphonomonoester nucleic acids process for their preparation and their use ,(1996)
Joseph Wang, Emil Palecek, Peter E Nielsen, Gustavo Rivas, Xiaohua Cai, Haruki Shiraishi, Narasaiah Dontha, Denbai Luo, Percio AM Farias, None, Peptide Nucleic Acid Probes for Sequence-Specific DNA Biosensors Journal of the American Chemical Society. ,vol. 118, pp. 7667- 7670 ,(1996) , 10.1021/JA9608050
Peter E. Nielsen, Michael Egholm, Ole Buchardt, Peptide nucleic acid (PNA). A DNA mimic with a peptide backbone. Bioconjugate Chemistry. ,vol. 5, pp. 3- 7 ,(1994) , 10.1021/BC00025A001