Amelioration of Metabolic Syndrome-Associated Cognitive Impairments in Mice via a Reduction in Dietary Fat Content or Infusion of Non-Diabetic Plasma.

摘要: Obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D) are associated with decreased cognitive function. While weight loss T2D remission result in improvements metabolism vascular function, it is less clear if these benefits extend to performance. Here, we highlight the malleable nature of MetS-associated dysfunction using a mouse model high fat diet (HFD)-induced MetS. learning memory was generally unaffected mice 1 (T1D), multiple impairments were MetS, including deficits novel object recognition, cued fear memory, spatial memory. However, brief reduction dietary content chronic HFD-fed led complete rescue Cerebral blood volume (CBV), measure perfusion, during long term recovered following intervention. Finally, repeated infusion plasma collected from age-matched, low diet-fed improved HFD mice, distinct profile. Thus, accompanying MetS appears be amenable treatment, related cerebrovascular mitigated by systemic factors.