Striatal hyperthermia associated with arousal: intracranial thermorecordings in behaving rats.

摘要: Abstract Humans and experimental animals show strong increases in body temperature response to a variety of stimuli presumed have stress as their common denominator. To assess the brain’s role this ‘emotional’ hyperthermia, temperatures were continuously recorded dorsal ventral striatum deep temporal muscle freely moving rats exposed different arousing mild (placement test cage, 20-s sound stimulation, i.v. saline injection, 3-min social interaction with conspecific, tail-pinch). The caused brain hyperthermia differing degrees but similar pattern, both striatum. Ventral had ∼0.4°C higher basal than striatum, each these was that muscle. Maximal (∼0.8–1.2°C for 20–40 min) occurred upon placement cages, during tail-pinch interaction, all which accompanied by behavioral activation. These developed short onset latencies (up 5–15 s) always preceded temperature. Significant smaller (∼0.2°C 4–6 detected after stimulation injection induced minimal changes behavior no change Thus, it appears can be triggered quite or stressful disturb an organism’s homeostasis demand adaptive responding. Although exact mechanisms local heat production tissue remain confirmed, neuronal activation primary triggering force behind are sufficient affect Because most neural processes temperature-dependent, may result dramatic modulation efficiency situations critical life-support behavior.