Association Between Antipsychotic Treatment and Advanced Diabetes Complications Among Schizophrenia Patients With Type 2 Diabetes Mellitus

摘要: Objective Antipsychotic drug use is an established risk factor for the development of type 2 diabetes mellitus. However, effect antipsychotic on progression complications remains unclear. This study aimed to explore association between treatment and advanced outcome among schizophrenia patients with diabetes. Methods The authors conducted a retrospective cohort using Taiwan's universal health insurance database. A total 17 629 newly-diagnosed were enrolled. mean duration follow-up, after excluding first 6-month observation period, was 4.8 years, ranged from 1 month 11.5 years. patterns within time window classified into none, irregular use, regular use. Antipsychotics further categorized high, intermediate, low metabolic risks. status exposure treated as time-dependent variables. outcomes measures included any complications, macrovascular microvascular all-cause mortality. Results Compared no in past 6 months, associated lower (adjusted hazard ratio, aHR = 0.81, 95% CI 0.69-0.95), (aHR 0.80, 0.66-0.97), mortality 0.73, 0.62-0.85). ratios antipsychotics 0.69 (95% 0.53-0.91), 0.82 0.68-0.99), 0.85 0.70-1.02), respectively. Conclusions Regular months reduced risks compared treatment.