Recombinant Organisms as Source of Cancer Biotherapeutics

摘要: The last fifteen years have witnessed a tremendous rise in new biological treatments for cancer. These treatments, collectively referred to as ’biological therapy,’are primarily based on stimulating the natural host immune response against cancerous cells. Biological therapies combination with chemotherapy, surgery, or radiation therapy started showing promise effective means treating New approaches been possible mainly because of increased knowledge cellular system and especially developments biotechnology. Recombinant DNA technology, example, has made it generate large amounts many compounds first time. novelty recombinant technology is precision efficiency which scientists can manipulate genes. ability isolate human genes insert them into microorganisms then produce proteins, thereby serving factories, revolutionized field therapy. Interferons special significance paradigm modifiers response. interest therapeutic potential interferon cancer viral diseases served catalyst emerging industry. Despite its great an antiviral agent, clinical application rather slow, lack methods producing adequate protein. Interest beyond virology began early 1960s, when workers recognize growth-inhibitory immuneactivation properties. During 1960s 1970s, reports interferon’s antitumor activity laboratory animals humans stirred up this several groups decided purify use.