The contribution of the mitochondrial genome to sex-specific fitness variance

摘要: Maternal inheritance of mitochondrial DNA (mtDNA) facilitates the evolutionary accumulation mutations with sex-biased fitness effects. Whereas maternal closely aligns mtDNA evolution natural selection in females, it makes indifferent to changes that exclusively benefit males. The constrained response males can lead asymmetries relative contributions genes female versus male variation. Here, we examine impact genetic drift and distribution effects (DFE) among – including correlation mutant between sexes on variation for fitness. We show how drift, correlations, skewness DFE determine variance. When are weakly correlated sexes, effective population size is large, should contribute much more than In contrast, high correlations small sizes tend equalize discuss implications these results genome diversity architecture fitness. This article protected by copyright. All rights reserved