Shrapnel nanoparticles loading docetaxel inhibit metastasis and growth of breast cancer.

摘要: Abstract Metastasis is one of the major obstacles for successful therapy breast cancer. To inhibit metastasis and growth cancer simultaneously, a new docetaxel (DTX) loaded shrapnel nano delivery system with reduction- enzyme-sensitive properties was designed developed. Firstly, methoxy polyethylene glycol-peptide-vitamin E succinate (PPV), matrix metalloproteinases (MMPs)-sensitive copolymer, synthesized by conjugating mPEG vitamin (VES) using an peptide. Then, DTX glycol-s-s-vitamin (PSV) micelles (DPM) @ PPV-based liposomes (DPM@PL) were prepared incorporation DPM into liposomes. DPM@PL showed structure average particle size 113.3 ± 2.7 nm. The drug loading encapsulation efficiency 1.93% 99.02%, respectively. An obvious burst release (>90%) observed in simulated tumor microenvironment MMPs reductive glutathione. cellular uptake cytotoxicity 4T1 cells significantly enhanced after pre-treatment activated MMP-9. Compared Taxotere ® , remarkably increased distribution lung tumor-bearing mice, inhibited situ pulmonary formation effectively through DTX-induced apoptosis reduced metastasis-promoting proteins expression. saline group, inhibitory rates against volume about 81% 92%, respectively, it didn't produce significant systemic toxicity. As result, could be promising