Physiological disposition of oral piracetam in Sprague-Dawley rats.

摘要: The distribution and fate of piracetam (2-oxo-1-pyrrolidine acetamide, Nootropil), the prototype ‘nootropic drug’, was examined in rats given 100–1000 mg kg−1 by gavage, with or without [3H]piracetam as a tracer. Peak serum concentrations were attained after 60 min. Its half-life disappearance from about 2 h during initial 8 administration then 6·4 for next 16 h. Brain equilibrated those at 4 h, which they fell exponentially but remained twice serum; brainstem lower (by 30–40%) than cortex, olfactory bulb, colliculi. No evidence could be obtained significant metabolism, either in-vivo when incubated liver homogenates. specific binding to any various subcellular fractions observed its along unlabelled carrier. Repeated daily doses (7 days, 100 kg−1) failed elevate brain beyond single dose.