Crohn's Colitis: The Incidence of Dysplasia and Adenocarcinoma in Surgical Patients

摘要: Data supporting an increased risk of colorectal cancer in patients with Crohn’s colitis are inconsistent. Despite this, clinical recommendations regarding colonoscopic screening and surveillance for extrapolated from chronic ulcerative protocols. The primary aim our study was to determine the incidence dysplasia carcinoma pathology specimens undergoing segmental or total colectomy disease large bowel. In addition, we sought identify factors associated development carcinoma. We performed a retrospective review all operated on at institution between January 1992 May 2004. were retrieved patient charts, operative notes, reports. Logistic regression used model probability having adenocarcinoma. Two hundred twenty-two (138 females) who underwent surgical resection treatment included study. Mean age surgery 41 (range, 15–82) years mean duration 10 0–53) years. There five cases (2.3 percent) six adenocarcinoma (2.7 percent). Three one diagnosed preoperative colonoscopy; while other discovered incidentally pathologic examination resected specimens. Factors presence older diagnosis (38.2 vs. 30.3 years, P = 0.02), longer (16.0 10.1 0.05), extent (90 percent extensive 59 limited, 0.05). Patients severe requiring significant developing adenocarcinoma, particularly when age, after duration, more colon involvement.