Gastrointestinal Vagal Afferents and Food Intake: Relevance of Circadian Rhythms.

摘要: Gastrointestinal vagal afferents (VAs) play an important role in food intake regulation, providing the brain with information on amount and nutrient composition of a meal. This is processed, eventually leading to meal termination. The response gastric VAs, food-related stimuli, under circadian control fluctuates depending time day. These rhythms are highly correlated size, nadir VA sensitivity increase size during dark phase peak decrease light mice. disrupted diet-induced obesity simulated shift work conditions associated patterns. In dampened responses not simply reversed by reverting back normal diet. However, restricted feeding prevents loss diurnal signalling high fat diet-fed mice and, therefore, provides potential strategy reset pre-obese phenotype. review discusses system regulation gastrointestinal signals impact factors, such as work, these rhythms.