A cross-species assessment of cognitive flexibility in compulsive disorders

摘要: Background: Obsessive-Compulsive Disorder (OCD) is a mental disorder featuring compulsions which are repetitive behaviors performed through rigid rituals. A diminished cognitive flexibility could explain this phenomenological observation. But studies exploring dimension have yet failed to show consistent deficits in OCD. In animal models of compulsive behavior, too few were performed, leaving the question open. The aim study was so assess involvement compulsion cross-species approach. Methods: 40 OCD patients, healthy comparison subjects individually matched, 26 C57BL/6J Sapap3 KO mice and matched wildtype littermates included study. reversal learning task similar both species used flexibility. Results: When considered as homogeneous groups, patients did not significantly differ from their controls. clinical subtypes considered, only exhibiting checking impaired with more trials needed reach criterion. mice, similarly subgroup identified. For species, impairment result greater perseveration after reversal, but lability responses condition. Moreover, correlate severity behaviors. Conclusions: Cognitive differentially affected across subgroups for species. This manifests itself response lability, perseveration, situation. first highlight such results.