Base excision repair in Archaea: back to the future in DNA repair.

作者: Stefano Grasso , Gianluca Tell

DOI: 10.1016/J.DNAREP.2014.05.006

关键词:

摘要: Together with Bacteria and Eukarya, Archaea represents one of the three domain life. In contrast morphological difference existing between these two domains are closely related. Phylogenetic analyses confirm this evolutionary relationship showing that most proteins involved in DNA transcription replication highly conserved. On contrary, information is scanty about repair pathways their mechanisms. present review important base excision repair, namely glycosylases, AP lyases, endonucleases, polymerases, sliding clamps, flap ligases, will be discussed compared bacterial eukaryotic ones. Finally, possible applications future perspectives derived from studies on pathways, taken into account.

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