[18F]fluorodeoxyglucose Uptake Patterns in Lung Before Radiotherapy Identify Areas More Susceptible to Radiation-Induced Lung Toxicity in Non-Small-Cell Lung Cancer Patients

摘要: Purpose Our hypothesis was that pretreatment inflammation in the lung makes pulmonary tissue more susceptible to radiation damage. The relationship between [ 18 F]fluorodeoxyglucose ([ F]FDG) uptake lungs (as a surrogate for inflammation) and delivered dose radiation-induced toxicity (RILT) investigated. Methods Materials We retrospectively studied prospectively obtained cohort of 101 non-small-cell cancer patients treated with (chemo)radiation therapy (RT). F]FDG-positron emission tomography-computed tomography (PET-CT) scans used treatment planning were studied. Different parameters describe F]FDG patterns lungs, excluding clinical target volumes, interaction dose. An increase dyspnea grade 1 (Common Terminology Criteria Adverse Events version 3.0) or points compared pre-RT score as an endpoint analysis RILT. effect CT-based variables, dose, other patient characteristics effected RILT using logistic regression. Results Increased density related after RT univariable 95th percentile remained significant multivariable regression ( p = 0.016; odds ratio [OR] 4.3), together age 0.029; OR=1.06), ≥1 0.005; OR=0.20). Significant effects demonstrated among 80th, 90th, percentiles relative volume receiving than 2 5 Gy. Conclusions risk increased tumor (OR 4.3). became pronounced fraction 5%, 10%, 20% highest standardized value voxels received Gy increased. Therefore, may be decreased by applying sophisticated radiotherapy techniques avoid areas high uptake.