Sex differences in neuroprotection provided by inhibition of TRPM2 channels following experimental stroke.

作者: Jia Jia , Saurabh Verma , Shin Nakayama , Nidia Quillinan , Marjorie R Grafe

DOI: 10.1038/JCBFM.2011.77

关键词:

摘要: … Similarly, we observe that TRPM2 inhibition with CTZ and shRNA virus decreased infarct size in male brain following experimental ischemia, while having no effect in female. Consistent …

参考文章(43)
Paco S. Herson, Patricia D. Hurn, Gender and the injured brain Progress in Brain Research. ,vol. 186, pp. 177- 187 ,(2010) , 10.1016/B978-0-444-53630-3.00012-9
A. Ardeshiri, M. H. Kelley, I. P. Korner, P. D. Hurn, P. S. Herson, Mechanism of progesterone neuroprotection of rat cerebellar Purkinje cells following oxygen-glucose deprivation. European Journal of Neuroscience. ,vol. 24, pp. 2567- 2574 ,(2006) , 10.1111/J.1460-9568.2006.05142.X
K Togashi, H Inada, M Tominaga, Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB). British Journal of Pharmacology. ,vol. 153, pp. 1324- 1330 ,(2008) , 10.1038/SJ.BJP.0707675
Robert Kraft, Christian Grimm, Henning Frenzel, Christian Harteneck, Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. British Journal of Pharmacology. ,vol. 148, pp. 264- 273 ,(2006) , 10.1038/SJ.BJP.0706739
Christian Harteneck, Henning Frenzel, Robert Kraft, N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker. Cardiovascular Drug Reviews. ,vol. 25, pp. 61- 75 ,(2007) , 10.1111/J.1527-3466.2007.00005.X
Patricia D. Hurn, Barbara J. Crain, Richard J. Traystman, A. Courtney DeVries, Kimihiko Hattori, Hanna Lee, Cognitive Deficits After Focal Cerebral Ischemia in Mice Stroke. ,vol. 31, pp. 1939- 1944 ,(2000) , 10.1161/01.STR.31.8.1939
Shuji Kaneko, Seiko Kawakami, Yuji Hara, Minoru Wakamori, Etsuko Itoh, Toshiyuki Minami, Yuki Takada, Toshiaki Kume, Hiroshi Katsuki, Yasuo Mori, Akinori Akaike, A critical role of TRPM2 in neuronal cell death by hydrogen peroxide Journal of Pharmacological Sciences. ,vol. 101, pp. 66- 76 ,(2006) , 10.1254/JPHS.FP0060128
Myron D. Ginsberg, Neuroprotection for ischemic stroke: past, present and future. Neuropharmacology. ,vol. 55, pp. 363- 389 ,(2008) , 10.1016/J.NEUROPHARM.2007.12.007
Melissa H. Kelley, Noriko Taguchi, Ardalan Ardeshiri, Masayuki Kuroiwa, Patricia D. Hurn, Richard J. Traystman, Paco S. Herson, Ischemic insult to cerebellar Purkinje cells causes diminished GABAA receptor function and allopregnanolone neuroprotection is associated with GABAA receptor stabilization. Journal of Neurochemistry. ,vol. 107, pp. 668- 678 ,(2008) , 10.1111/J.1471-4159.2008.05617.X
Elaine Besancon, Shuzhen Guo, Josephine Lok, Michael Tymianski, Eng H. Lo, Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke. Trends in Pharmacological Sciences. ,vol. 29, pp. 268- 275 ,(2008) , 10.1016/J.TIPS.2008.02.003