Concentration of serum interleukin-27 increase in patients with lymph node metastatic gastroesophageal cancer.

摘要: BACKGROUND Cytokines, one of the key mediators immune response, play an important role in cancer development. OBJECTIVES The aim this study was to evaluate interleukin-27 (IL-27) concentration serum patients with gastroesophageal (GEC) and non-cancerous benign diseases upper digestive tract (NCD). We investigated relationship between IL-27 level clinicopathological factors, also diagnostic utility as a marker GEC presence. Additionally, we evaluated concentrations esophageal squamous cell carcinoma before after surgical tumor resection. MATERIAL AND METHODS Serum samples from 84 patients, 39 NCD 33 healthy subjects were assayed. levels IL-27, IL-6, IL-12 IFN-γ determined using ELISA kits. RESULTS significantly higher than control (p < 0.0001) = 0.006). related lymph node status 0.044). ROC analysis showed significant high presence (AUC 0.766, p 0.001). 3 months esophagectomy operation 0.003). CONCLUSIONS Our results demonstrated that is associated metastases GEC. Significantly resection may imply host cells are sources circulating IL-27.