Folic acid supplementation improves vascular function in amenorrheic runners.

作者: Anne Z Hoch , Stacy L Lynch , Jason W Jurva , Jane E Schimke , David D Gutterman

DOI: 10.1097/JSM.0B013E3181DF59F4

关键词:

摘要: OBJECTIVE The purpose of this study was to determine if folic acid supplementation improves endothelial vascular function (brachial artery flow-mediated dilation; FMD) in amenorrheic runners. DESIGN Prospective cross-sectional study. SETTING Academic medical center the Midwest. PARTICIPANTS Ten and 10 eumenorrheic women runners from community volunteered for INTERVENTIONS Each participant treated with (10 mg/d) 4 weeks. MAIN OUTCOME MEASURES Brachial FMD measured before after standard techniques. RESULTS brachial response reactive hyperemia improved (3.0% +/- 2.3% vs. 7.7% 4.5%; P = 0.02). In control group, there no change (6.7% 2.0% 5.9% 2.6%; 0.52). CONCLUSIONS This demonstrates that FMD, an indicator function, female short-term acid.

参考文章(45)
David S Celermajer, Endothelial Dysfunction: Does It Matter? Is It Reversible? Journal of the American College of Cardiology. ,vol. 30, pp. 325- 333 ,(1997) , 10.1016/S0735-1097(97)00189-7
Masayoshi Hashimoto, Masahiro Akishita, Masato Eto, Michiro Ishikawa, Koichi Kozaki, Kenji Toba, Yoko Sagara, Yuji Taketani, Hajime Orimo, Yasuyoshi Ouchi, Modulation of Endothelium-Dependent Flow-Mediated Dilatation of the Brachial Artery by Sex and Menstrual Cycle Circulation. ,vol. 92, pp. 3431- 3435 ,(1995) , 10.1161/01.CIR.92.12.3431
Masahide Ohmichi, Yuki Kanda, Koji Hisamoto, Ken-ichiro Morishige, Kazuhiro Takahashi, Kenjiro Sawada, Ryoko Minekawa, Keiichi Tasaka, Yuji Murata, Rapid changes of flow-mediated dilatation after surgical menopause Maturitas. ,vol. 44, pp. 125- 131 ,(2003) , 10.1016/S0378-5122(02)00320-1
Claudia Walther, Stephan Gielen, Rainer Hambrecht, The effect of exercise training on endothelial function in cardiovascular disease in humans. Exercise and Sport Sciences Reviews. ,vol. 32, pp. 129- 134 ,(2004) , 10.1097/00003677-200410000-00002
Maro R. I. Williams, Roderick A. Westerman, Bronwyn A. Kingwell, Jason Paige, Peter A. Blombery, Krishnankutty Sudhir, Paul A. Komesaroff, Variations in Endothelial Function and Arterial Compliance during the Menstrual Cycle The Journal of Clinical Endocrinology & Metabolism. ,vol. 86, pp. 5389- 5395 ,(2001) , 10.1210/JCEM.86.11.8013
Schutte, Huisman, Oosthuizen, van Rooyen, Jerling, Cardiovascular Effects of Oral Supplementation of Vitamin C, E and Folic Acid in Young Healthy Males International Journal for Vitamin and Nutrition Research. ,vol. 74, pp. 285- 293 ,(2004) , 10.1024/0300-9831.74.4.285
N Pancharuniti, C A Lewis, H E Sauberlich, L L Perkins, R C Go, J O Alvarez, M Macaluso, R T Acton, R B Copeland, A L Cousins, T B Gore, P E Cornwell, J M Roseman, Plasma homocyst(e)ine, folate, and vitamin B-12 concentrations and risk for early-onset coronary artery disease. The American Journal of Clinical Nutrition. ,vol. 59, pp. 940- 948 ,(1994) , 10.1093/AJCN/59.4.940
Kam S Woo, Ping Chook, Yvette I Lolin, John E Sanderson, Con Metreweli, David S Celermajer, Folic acid improves arterial endothelial function in adults with hyperhomocystinemia Journal of the American College of Cardiology. ,vol. 34, pp. 2002- 2006 ,(1999) , 10.1016/S0735-1097(99)00469-6