Glycosylation of prostate specific antigen and its potential diagnostic applications
作者： Tijl Vermassen , Marijn M. Speeckaert , Nicolaas Lumen , Sylvie Rottey , Joris R. Delanghe
DOI: 10.1016/J.CCA.2012.06.007
关键词:
摘要: Prostate specific antigen (PSA) assays are widely used for early detection of prostate cancer. However, those analyses associated with considerable sensitivity and specificity problems. Several approaches have been developed to tackle this issue. PSA is a glycoprotein, which primarily produced by the prostatic epithelial cells. Aberrant glycosylation modification proteins fundamental characteristic tumorigenesis. Study glycoforms offers interesting diagnostic perspectives. Modern technology allows us analyze in variety clinical samples (serum or plasma, urine, seminal fluid, tissue). A number novel techniques, such as lectin-based methods, mass spectrometry, 2-dimensional electrophoresis capillary glycosylation. This article reviews technical aspects glycoforms.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(92)
Daniel W Chan, Yong-Ming Gao, Variants of prostate-specific antigen separated by concanavalin A. Clinical Chemistry. ,vol. 37, pp. 1133- 1134 ,(1991) , 10.1093/CLINCHEM/37.6.1133
David Wild, The Immunoassay Handbook ,(2001)
Sen-itiroh Hakomori, Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens Advances in Cancer Research. ,vol. 52, pp. 257- 331 ,(1989) , 10.1016/S0065-230X(08)60215-8
R N Knibbs, I J Goldstein, R M Ratcliffe, N Shibuya, Characterization of the carbohydrate binding specificity of the leukoagglutinating lectin from Maackia amurensis. Comparison with other sialic acid-specific lectins. Journal of Biological Chemistry. ,vol. 266, pp. 83- 88 ,(1991) , 10.1016/S0021-9258(18)52405-4
K. Kornfeld, M.L. Reitman, R. Kornfeld, The carbohydrate-binding specificity of pea and lentil lectins. Fucose is an important determinant. Journal of Biological Chemistry. ,vol. 256, pp. 6633- 6640 ,(1981) , 10.1016/S0021-9258(19)69037-X
Lee Van Lenten, Gilbert Ashwell, Studies on the chemical and enzymatic modification of glycoproteins. A general method for the tritiation of sialic acid-containing glycoproteins. Journal of Biological Chemistry. ,vol. 246, pp. 1889- 1894 ,(1971) , 10.1016/S0021-9258(18)62392-0
Tsutomu Kawaguchi, Isamu Matsumoto, Toshiaki Osawa, Studies on hemagglutinins from Maackia amurensis seeds. Journal of Biological Chemistry. ,vol. 249, pp. 2786- 2792 ,(1974) , 10.1016/S0021-9258(19)42698-7
W C Wang, R D Cummings, The immobilized leukoagglutinin from the seeds of Maackia amurensis binds with high affinity to complex-type Asn-linked oligosaccharides containing terminal sialic acid-linked alpha-2,3 to penultimate galactose residues. Journal of Biological Chemistry. ,vol. 263, pp. 4576- 4585 ,(1988) , 10.1016/S0021-9258(18)68821-0
Toyohiro Okada, Yuji Sato, Norifumi Kobayashi, Kyoichi Sumida, Shinji Satomura, Shuji Matsuura, Masaru Takasaki, Tamao Endo, Structural characteristics of the N-glycans of two isoforms of prostate-specific antigens purified from human seminal fluid1This paper is a part of the dissertation submitted by T.O. to Tokyo Medical University as a requirement for the degree of Doctor of Medical Sciences.1 Biochimica et Biophysica Acta (BBA) - General Subjects. ,vol. 1525, pp. 149- 160 ,(2001) , 10.1016/S0304-4165(00)00182-3
S Hakomori, E H Holmes, G K Ostrander, Biosynthesis of the sialyl-Lex determinant carried by type 2 chain glycosphingolipids (IV3NeuAcIII3FucnLc4, VI3NeuAcV3FucnLc6, and VI3NeuAcIII3V3Fuc2nLc6) in human lung carcinoma PC9 cells. Journal of Biological Chemistry. ,vol. 261, pp. 3737- 3743 ,(1986) , 10.1016/S0021-9258(17)35709-5