Role of antigen presentation in the production of pro-inflammatory cytokines in obese adipose tissue.

摘要: Type II diabetes regroups different physiological anomalies that ultimately lead to low-grade chronic inflammation, insulin resistance and loss of pancreatic β-cells. Obesity is one the best examples such a condition can develop into Metabolic Syndrome, causing serious health problems great socio-economic consequences. The pathological outcome obesity has genetic basis depends on delicate balance between pro- anti-inflammatory effectors immune system. causal link inflammation well established. While innate immunity plays key role in development pro-inflammatory state obese adipose tissues, it now become clear adaptive cells are also involved participate cascade events metabolic perturbations. efficacy some immunotherapeutic protocols reducing symptoms obesity-driven syndrome mice implicated all arms response. Recently, production pathogenic immunoglobulins cytokines by B T lymphocytes suggested an auto-immune for establishment non-healthy state. Understanding cellular landscape tissues how sustain holds targeted therapies. In this review, we emphasize antigen-presenting MHC molecules tissue general contribution arm system inflammation-induced resistance.