A Library of Well-Defined and Water-Soluble Poly(alkyl phosphonate)s with Adjustable Hydrolysis
作者： Thomas Wolf , Tobias Steinbach , Frederik R. Wurm
DOI: 10.1021/ACS.MACROMOL.5B00897
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摘要: Poly(alkyl ethylene phosphonate)s with different alkyl side chains exhibit significant differences in their degradation behavior. Three novel 2-alkyl-2-oxo-1,3,2-dioxaphospholanes, cyclic monomers for the ring-opening polymerization (ROP) toward poly(alkyl alkylene phosphonate)s, were synthesized by robust two- or three-step protocols reasonable yields and high purity. The was promoted organocatalysts 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) proceeded control over molecular weight narrow distributions (Đ < 1.2) up to full conversion. These polymers methyl, ethyl, isopropyl are perfectly soluble water (up 25 mg mL–1) without a temperature-dependent phase separation. They showed no toxicity against HeLa cells after 24 h of incubation at any tested concentration. Polymers butyl decreased solubility concentration-dependent cloud point temperatures an...
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