Evidence for excess colorectal cancer incidence among asbestos-exposed men in the Beta-Carotene and Retinol Efficacy Trial

摘要: The relation between asbestos exposure and colorectal cancer remains controversial. authors of this 1984-2004 US study examined the association among 3,897 occupationally exposed participants in Beta-Carotene Retinol Efficacy Trial (CARET) for chemoprevention lung cancer, followed prospectively 10-18 years. When a Cox stratified proportional hazards model was used, risks were elevated male heavy smokers to asbestos. Their relative risk 1.36 (95% confidence interval: 0.96, 1.93) when compared with that CARET not asbestos, after adjusting age, smoking history, intervention arm. presence asbestos-induced pleural plaques at baseline associated 1.54 0.99, 2.40); also increased worsening pulmonary asbestosis (p = 0.03 trend). A dose-response trend based on years less evident. Nonetheless, these data suggest is men especially those evidence nonmalignant asbestos-associated radiographic changes.