Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene.

摘要: Abstract The unusual electron microscopic appearance of a hybrid formed between 9S mouse beta-globin mRNA and its corresponding cloned gene segment is caused by at least one, possibly two, intervening sequences DNA that interrupt the gene. Such an interpretation consistent with paradoxical restriction site pattern previously noted in this nucleotide sequence portion spans both structural sequences. The large sequence, approximately 550 base pairs length, occurs globin immediately follows codon to amino acid 104. A smaller, putative located close 5' end beta-globin-coding but may reside beyond initiation codon. thus appears be encoded three, discontinuous segments.