作者: Thomas Eitinger
DOI: 10.1002/9781119951438.EIBC2118
关键词:
摘要: Nickel and cobalt ions are required by prokaryotes for incorporation into diverse enzymes involved in central metabolic reactions. The metal taken up from the environment selective high-affinity primary secondary active transport systems. These systems discriminate between Ni2+ Co2+ on one side other divalent transition side. Despite similar properties of Co2+, a couple uptake exist that efficiently distinguish even those two cations. Relevant transporters include canonical energy-coupling factor-type ATP-binding cassette importers members nickel/cobalt transporter family relatives latter. Recent advances discovery nickel across outer membrane gram-negative bacteria TonB-dependent tentative identification an unusual metallophore uptake. Export avoid cellular overload with comprise multimeric resistance-nodulation-cell division family, different subgroups, P-type ATPases. Keywords: ABC transporter; ECF transporter; nickel/cobalt transporter; metal resistance; resistance-nodulation-cell division; TonB-dependent outer-membrane transporter; P-type ATPase