摘要: There is increasing evidence that the black box we have referred to as"biologic aging" composed of genetic factors and many types environmental exposures. Some most potentially modifiable elements this syndrome are those attributable disuse or insufficient exposure certain kinds intensities physical stressors during course life span. Beneficial adaptations exercise once thought restricted genetically endowed master athletes now seen occur just as predictably in frail elders with chronic disease, opening door vastly improved function associated health benefits. Knowledge benefits activity, however well substantiated, may be necessary, but it not sufficient change either physician-prescribing habits likelihood adoption long-term adherence on part patients. Ultimately, penetration an prescription optimize aging into inactive cohorts community,who gain from increases levels activity fitness, will depend a combination clear evidence-based guidelines coupled professional training behavioral programs tailored age-specific barriers motivational factors.