Rat hair follicle stem cells differentiate and promote recovery following spinal cord injury.
作者： Maliheh Nobakht , Bagher Pourheydar , Mohammad Ghasem Golmohammadi , Nowruz Najafzadeh
DOI: 10.3969/J.ISSN.1673-5374.2013.36.001
关键词:
摘要: Emerging studies of treating spinal cord injury (SCI) with adult stem cells led us to evaluate the effects transplantation hair follicle in rats a compression-induced lesion. Here, we proposed hypothesis that rat cell can promote recovery injured cord. Compression-induced was induced Wistar this study. The bulge area vibrissa follicles isolated, cultivated and characterized nestin as marker. 5-Bromo-2′-deoxyuridine (BrdU) labeled were transplanted into injury. Immunohistochemical staining results showed some grafted could survive differentiate oligodendrocytes (receptor-interacting protein positive cells) neuronal-like (βIII-tubulin at 3 weeks after transplantation. In addition, hind limb locomotor function 8 following assessed using Basso, Beattie Bresnahan (BBB) rating scale. demonstrate for long time period vivo neuronal- glial-like cells. These suggest
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