Saccharide Receptor-Mediated Drug Delivery

摘要: Since the pioneering work of Ashwell and Morell on in-vivo plasma clearance desialylated serum glycoproteins, 1 concept has become widely accepted that exposed sugar residues glycoproteins serve as determinants for (i.e., clearance) in-vitro uptake) recognition. Carbohydrate-mediated endocytosis in mammals since subject intensive studies.2,3 Mammalian hepatic receptors are known to be specific terminal D-galactose glycoproteins;4 whereas avian liver, recognize 2-acetamido-2-deoxy-D-glucose residues.5 Hepatocytes also contain a receptor binds specifically through L-fucose α (1→3) linkage 2-ace-tamido-2-deoxy-D-glucose.6 Macrophages Kupffer cells have been shown bind synthetic neoglycoconjugates D-mannose non-reducing position.7,8 The uptake some lysosomal enzymes by fibroblasts involves recognition 6-phosphate.9