Novel progesterone receptors: neural localization and possible functions.

摘要: Progesterone (P4) regulates a wide range of neural functions and likely acts through multiple receptors. Over the past 30 years, most studies investigating effects P4 focused on genomic non-genomic actions classical progestin receptor (PGR). More recently focus has widened to include two groups non-classical signaling molecules. Members Class II adipoQ (PAQR) family are called membrane receptors (mPRs) include: mPRα (PAQR7), mPRβ (PAQR8), mPRγ (PAQR5), mPRδ (PAQR6) mPRe (PAQR9). b5-like heme/steroid-binding protein progesterone component 1 (PGRMC1), PGRMC2, neudesin neuferricin. Results our recent mapping show that members PGRMC1/S2R family, but not mPRs, quite abundant in forebrain structures important for neuroendocrine regulation other P4. Herein we describe structures, neuroanatomical localization mechanisms these We also discuss possible roles Pgrmc1/S2R gonadotropin release, feminine sexual behaviors, fluid balance neuroprotection, as well catamenial epilepsy.