Genomic and genetic alterations influence the progression of gastric cancer

摘要: Gastric cancer is one of the leading causes cancer-related deaths worldwide, although incidence has gradually decreased in many Western countries. Two main gastric histotypes, intestinal and diffuse, are recognised. Although most described genetic alterations have been observed both types, different pathways hypothesized. Genetic epigenetic events, including 1q loss heterozygosity (LOH), microsatellite instability hypermethylation, mostly reported intestinal-type carcinoma its precursor lesions, whereas 17p LOH, mutation or E-cadherin more often implicated development diffuse-type cancer. In this review, we summarize sometimes contradictory findings regarding those markers which influence progression adenocarcinoma.