INSULIN GENE VARIABLE NUMBER OF TANDEM REPEAT GENOTYPE, EARLY GROWTH AND GLUCOSE METABOLISM IN ADULT LIFE

摘要: he predisposition to type 2 diabetes is programmed early in life and genotypes promoting survival during nutritional adversity could increase the risk of diabetes. The insulin gene variation in variable number of tandem repeats (VNTR) polymorphism has been suggested modify birth size susceptibility. Materials Methods: We assessed association between VNTR genotypes, early growth glucose metabolism in adult 488 subjects participating in the Helsinki Birth Cohort Study. Results: Body at did not differ significantly between INS genotypes. One additional III allele was associated with a 13 g decrease (95% CI -55 81 g; p=0.7) birth weight. Fasting concentration highest in carriers III/III genotype. The cumulative incidence not differ between Interactions between birth genotype in relation fasting (p for interaction = 0.08 weight, p=0.05 length) and 2-hour =0.04) were observed. Conclusions: These interactions body size reflect between the intrauterine environment. Our findings are consistent with hypothesis developmental plasticity, where one can give rise different phenotypes dependent on environment.