Active Immunotherapy in Leukemia With Neuraminidase-Modified Leukemic Cells*

摘要: The enzymic cleavage of the terminal sugar residue from plasma membrane neoplastic cells by neuraminidase vibrio cholerae origin causes a marked increase in immunogenicity most experimental tumors [1–6, 8–16]. In DBA/2 leukemia L1210 system, single leukemic cell is capable producing and ultimate death host. However, mice which were immunized with neuraminidase-treated remained protected against challenge 100,000 untreated [1–3]. Repeated injections reduced lethality rate increased survival tumor grafts [15, 16]. Chemotherapy plus administered sequence preserves host’s immunobiologically competent resulted cure significant portion [4, 7, 9]. immunoprotection evoked stimulation was specific for particular could be transferred sera or splenic lymphocytes into unimmunized syngeneic [5, 15, Recently, considerable attention has been directed to combined modality therapy spontaneous Gross virus-induced AkR because many respects similar characteristics human leukemias.