Intensified Chemotherapy with Stem Cell Support for Solid Tumors in Adults: 30 Years of Investigations Can Provide Some Clear Answers?

摘要: High-dose chemotherapy (HDC) with autologous hematopoietic stem cell transplantation (AHSCT) was first introduced as an experimental treatment for solid tumours in the late seventies (1). The basic line such extremely simple: can grams work where milligrams fail? Initial data were from pediatric tumors, but soon after incredible amount of came germ tumor (GCT), breast carcinoma (BC), small lung cancer (SCLC), ovarian and nearly all types have been treated, many them reported anecdotal. After more than thirty years investigations we are now position giving a lookout what happened why some questions received answer others did not. “rush to transplantation” early times led thousands patients (pts) treated modality, BC being most preferred indication 2,000 pts per year nineties only Europe (2). Unfortunately, vast majority those outside clinical trials, so level evidence remained at lowest level. Nevertheless important studies conducted least robust provided. This article will try clarify this still fascinating probably not exhausted field. We consider due huge available, then other tumors which HDC has widely utilized.