Regulation of Oestrogen Action: Role of 17β-hydroxysteroid Dehydrogenases

摘要: The target cell responses to steroid hormones, such as oestrogens, are dependent on the expression of their receptors. Apart from receptor concentration, another key regulatory factor in hormone action is intracellular which affected by three main variables: concentration plasma, local production and conversion into metabolites. During reproductive years source oestrogens ovarian follicle, but postmenopausal women most formed peripheral tissues. present overview deals with formation active steroidogenic tissues oestrogen tissues, focus 17β-hydroxysteroid dehydrogenases, catalyse interconversion between oestradiol oestrone. It evident that different dehydrogenase isoenzymes responsible for oxidation/ reduction or oestrone cells. Because these enzymes inv...