EFFECTS OF ANTISERUM TO LUTEINIZING HORMONE ON THE STRUCTURE AND FUNCTION OF RAT LEYDIG CELLS

摘要: The influence of LH on morphology and function Leydig cells was investigated in adult rats by selective neutralization endogenous hormone with specific antibodies. Administration antiserum to mature male Sprague-Dawley for 8 days caused a significant decrease testis weight levels testosterone serum but had no effect the overall number interstitial per testis. ability isolated from antiserum-treated animals produce response exogenous also significantly lower than that derived treated normal rabbit serum. Although similar control groups, morphological studies indicated major fully differentiated animals. Furthermore, resulted disruption endoplasmic reticulum accumulation dense bodies resembling lysosomes cells. These results suggested primary trophic action is induce maintain steroidogenic capacity