Noninvasive surface detection of papillary thyroid carcinoma by Fourier transform infrared spectroscopy

摘要: Previously Fourier transform infrared(FTIR) spectroscopy has been applied to detecting thyroid cancer during operations and discriminating cervical metastatic ones from non-metastatic lymph nodes. This study explored the possibility of establishing a sensitive, accurate noninvasive screen or diagnosis by preoperative FTIR spectroscopy. 111 patients undergone operation 50 healthy volunteers were enrolled in study. The spectra obtained two mid-infrared optical fibers with an attenuated total reflectance(ATR) probe closely contacting subjects’ skin on nodules. normal thyroid, nodular goiter(NG) papillary carcinoma(PTC) compared. A Fisher’s discriminant analysis was created based these data. There 41 PTC 70 NG according their histopathological examinations. 23(of 39) parameters statistically different among three groups(P<0.05). F1300 F1080 significantly between groups. In total, 9 out 39 selected as independent factors Wilks’ lambda stepwise analysis. discrimination accuracy carcinoma groups 88.8%. Surface detection is feasible. can be used for rapid auxiliary diagnosis.