Toxic Epidermal Necrolysis Caused by "Gin and Tonic"

摘要: To the Editor.— Over 100 different drugs have been incriminated as possible causes of toxic epidermal necrolysis. We believe that we a patient who is sensitive to small quantity quinine present in tonic water. In August 1972, initially saw 55-year-old white man consultation for evaluation an almost yearly recurrence desquamation and peeling large areas his skin. For five-year period, stated that, while otherwise excellent health, he would annually experience burning sensation palms soles, which be followed by generalized redness ultimately eventuating During these times, also occasionally noted mild sore throat feeling malaise. Careful questioning revealed no specific relationship concurrent illnesses or known ingestion drugs. As example, was told