Molecular mechanisms of Barrett's esophagus.
作者： Hao Chen , Yu Fang , Whitney Tevebaugh , Roy C. Orlando , Nicholas J. Shaheen
DOI: 10.1007/S10620-011-1885-6
关键词:
摘要: Barrett's esophagus (BE) is defined as the metaplastic conversion of esophageal squamous epithelium to intestinalized columnar epithelium. As a premalignant lesion adenocarcinoma (EAC), BE develops result chronic gastroesophageal reflux disease (GERD). Many studies have been conducted understand molecular mechanisms this disease. This review summarizes recent results involving and intestinal transcription factors, signaling pathways, stromal microRNAs, other factors in development BE. A conceptual framework proposed guide future studies. We expect elucidation help improved management GERD, BE, EAC.
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Maria van der Sluis, Audrey Vincent, Janneke Bouma, Anita Korteland-Van Male, Johannes B. van Goudoever, Ingrid B. Renes, Isabelle Van Seuningen, Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells. Biochemical and Biophysical Research Communications. ,vol. 369, pp. 1108- 1113 ,(2008) , 10.1016/J.BBRC.2008.02.158
Wei-Yuan Yu, Jonathan M.W. Slack, David Tosh, Conversion of columnar to stratified squamous epithelium in the developing mouse oesophagus Developmental Biology. ,vol. 284, pp. 157- 170 ,(2005) , 10.1016/J.YDBIO.2005.04.042
Ajay Bansal, I H Lee, X Hong, V Anand, S C Mathur, S Gaddam, A Rastogi, S B Wani, N Gupta, M Visvanathan, P Sharma, L K Christenson, Feasibility of MicroRNAs as Biomarkers for Barrett's Esophagus Progression: A Pilot Cross-Sectional, Phase 2 Biomarker Study The American Journal of Gastroenterology. ,vol. 106, pp. 1055- 1063 ,(2011) , 10.1038/AJG.2011.37
Toshihiro Uesaka, Noriko Kageyama, Hiromitsu Watanabe, Identifying target genes regulated downstream of Cdx2 by microarray analysis Journal of Molecular Biology. ,vol. 337, pp. 647- 660 ,(2004) , 10.1016/J.JMB.2004.01.061
A. D'Angelo, O. Bluteau, M. A. Garcia-Gonzalez, L. Gresh, A. Doyen, S. Garbay, S. Robine, M. Pontoglio, Hepatocyte nuclear factor 1α and β control terminal differentiation and cell fate commitment in the gut epithelium Development. ,vol. 137, pp. 1573- 1582 ,(2010) , 10.1242/DEV.044420
Hiroshi Fukamachi, Runx3 controls growth and differentiation of gastric epithelial cells in mammals Development, Growth and Differentiation. ,vol. 48, pp. 1- 13 ,(2006) , 10.1111/J.1440-169X.2006.00832.X
Boni Anatole Afouda, Aldo Ciau-Uitz, Roger Patient, GATA4, 5 and 6 mediate TGFβ maintenance of endodermal gene expression in Xenopus embryos Development. ,vol. 132, pp. 763- 774 ,(2005) , 10.1242/DEV.01647
Helene Geddert, Sibylle Kiel, Hans Jörg Heep, Helmut Erich Gabbert, Mario Sarbia, The role of p63 and ΔNp63 (p40) protein expression and gene amplification in esophageal carcinogenesis Human Pathology. ,vol. 34, pp. 850- 856 ,(2003) , 10.1016/S0046-8177(03)00342-3
Roy W. Phillips, Henry F. Frierson,, Christopher A. Moskaluk, Cdx2 as a Marker of Epithelial Intestinal Differentiation in the Esophagus The American Journal of Surgical Pathology. ,vol. 27, pp. 1442- 1447 ,(2003) , 10.1097/00000478-200311000-00006
Yaron Daniely, Grace Liao, Darlene Dixon, R. Ilona Linnoila, Adriana Lori, Scott H. Randell, Moshe Oren, Anton M. Jetten, Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium American Journal of Physiology-cell Physiology. ,vol. 287, ,(2004) , 10.1152/AJPCELL.00226.2003