Personality Mediation of Genetic Effects on Attention-Deficit/Hyperactivity Disorder
作者： Michelle M. Martel , Molly Nikolas , Katherine Jernigan , Karen Friderici , Joel T. Nigg
DOI: 10.1007/S10802-010-9392-3
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摘要: Personality traits may be viable candidates for mediators of the relationship between genetic risk and ADHD. Participants were 578 children (331 boys; 320 with ADHD) ages six 18. Parents teachers completed a comprehensive, multi-stage diagnostic procedure to assess ADHD comorbid disorders. Mother California Q-Sort child Big Five personality traits. Children provided buccal samples DNA which assayed selected markers on DRD4, DAT1, ADRA2A. An additive composite was associated symptoms maladaptive traits; symptoms. Low conscientiousness high neuroticism partially mediated Mediation effects specific inattentive symptoms; generalized all disruptive behaviors. High low useful as early at
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