Dissolution behavior of co-amorphous amino acid-indomethacin mixtures: The ability of amino acids to stabilize the supersaturated state of indomethacin
作者： Rami Ojarinta , Aki T. Heikkinen , Elina Sievänen , Riikka Laitinen
DOI: 10.1016/J.EJPB.2016.11.023
关键词:
摘要: Arginine, phenylalanine, and tryptophan have been previously shown to improve the solid-state stability of amorphous indomethacin. The present study investigates the ability of these amino acids to prolong the supersaturation of indomethacin in both aqueous and biorelevant conditions either when freely in solution or when formulated as co-amorphous mixtures. The co-amorphous amino acid-indomethacin mixtures (molar ratio 1: 1) and amorphous indomethacin were prepared by cryomilling. Dissolution and precipitation tests …
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