Vascular plasticity in cerebrovascular disorders.

摘要: Cerebral ischemia remains a major cause of morbidity and mortality with little advancement in subacute treatment options. This review aims to cover discuss novel insight obtained during the last decade into plastic changes vasoconstrictor receptor profiles cerebral arteries microvessels that takes place after different types stroke. Receptors like endothelin type B, angiotensin 1, 5-hydroxytryptamine 1B/1D receptors are upregulated smooth muscle layer ischemic stroke as well subarachnoid hemorrhage, yielding rather dramatic contractility vessels. Some signal transduction processes mediating this upregulation have been elucidated. In particular extracellular regulated kinase 1/2 pathway, which is activated early process, has proven be promising therapeutic target for prevention Together, those findings provide new perspectives on pathophysiology point toward way reducing vasoconstriction, neuronal cell death, thus neurologic deficits