SU‐GG‐J‐125: Monte Carlo Simulation of Dose Enhancement in Tumors Using Gold Nanoparticles

摘要: Purpose: In the radiation oncology setting, high atomic number (Z) nanoparticles may provide a local dose enhancement in tumors when combined with low energy x‐rays. At energies near K‐shell edges of these materials, mass absorption coefficient (μen/ρ) be significantly higher than that tissue. For materials such as gold, edge falls lower spectrum conventional CT scanner. Irradiating inside tumor scanner to while sparing healthy surrounding As first step, simulation goldnanoparticles phantom can quantify magnitude this effect. Methods:Monte Carlo simulations were performed for different concentrations gold using program MCNPX. Simulations cylindrical having various goldnanoparticles. Four used: no 1mg/g, 5mg/g, 10mg/g. The source was modeled 140kVP Each scenario run 109 particles. Results: all cases, total deposited target determined. These calculations indicate provides sizeable increase target. and 10mg/g nanoparticle concentration increases 1.13, 1.78, 2.58 times relative gold.Conclusions:Monte irradiated by an x‐ray reveal presence. Dose enhancements over 2.5 up localizing effective at providing improved therapeutic ratio. results used guide measurements confirmation Supported Dept Army — USAMRRA W91ZSQ9081N608.