Impaired long‐term potentiation–like cortical plasticity in presymptomatic genetic frontotemporal dementia
作者： Alberto Benussi , Maura Cosseddu , Ilaria Filareto , Valentina Dell'Era , Silvana Archetti
DOI: 10.1002/ANA.24731
关键词:
摘要: Neurophysiological biomarkers were assessed using a transcranial magnetic stimulation multiparadigm approach in 13 presymptomatic (n = 13 Granulin) and 14 symptomatic (n = 11 Granulin, n = 3 C9orf72) subjects with pathogenic mutation for frontotemporal dementia (FTD). Intracortical facilitation long-term potentiation-like plasticity impaired carriers, compared to healthy controls, more than 15 years before expected symptom onset. In decrease short-interval intracortical inhibition, was found. conclusion, these could provide the footprints of specific physiopathological processes development this disease possibly support diagnosis autosomal-dominant FTD. Ann Neurol 2016;80:472-476.
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