Analysis and Immunological Properties of Lymphadenopathy Associated Virus (LAV) Structural Proteins

作者: F. Barre-Sinoussi , J. C. Chermann , L. Montagnier

DOI: 10.1007/978-1-4612-5008-1_30

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摘要: LAV or related viruses were isolated from patients with AIDS lymphadenopathy. The results presented here indicate that four major components (p45, p25, pl8 and pl3) are detected in purified virions. p25 the pl3 internal proteins of since they cannot be easily iodinated can by phosphocellulose chromatography protein labelled I. is either a gag gene product transmembrane protein. core different viral isolates antigenically identical but not to structural other retroviruses. Antibodies predominantly found sera pre-AIDS some cases, antibodies also detected. These confirm various represent new human retroviruses associated AIDS.

参考文章(9)
F. Brun-Vezinet, F. Barre-Sinoussi, A.G. Saimot, D. Christol, L. Montagnier, C. Rouzioux, D. Klatzmann, W. Rozenbaum, J.C. Gluckmann, J.C. Chermann, DETECTION OF IgG ANTIBODIES TO LYMPHADENOPATHY-ASSOCIATED VIRUS IN PATIENTS WITH AIDS OR LYMPHADENOPATHY SYNDROME The Lancet. ,vol. 323, pp. 1253- 1256 ,(1984) , 10.1016/S0140-6736(84)92444-9
F Barre-Sinoussi, J. Chermann, F Rey, M. Nugeyre, S Chamaret, J Gruest, C Dauguet, C Axler-Blin, F Vezinet-Brun, C Rouzioux, W Rozenbaum, L Montagnier, Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science. ,vol. 220, pp. 868- 871 ,(1983) , 10.1126/SCIENCE.6189183
P. Feorino, V. Kalyanaraman, H. Haverkos, C. Cabradilla, D. Warfield, H. Jaffe, A. Harrison, M. Gottlieb, D Goldfinger, J. Chermann, al. et, Lymphadenopathy associated virus infection of a blood donor--recipient pair with acquired immunodeficiency syndrome Science. ,vol. 225, pp. 69- 72 ,(1984) , 10.1126/SCIENCE.6328663
Vaniambadi S Kalyanaraman, Cirilo D Cabradilla, Jane P Getchell, R Narayanan, Erwin H Braff, J-C Chermann, Françoise Barré-Sinoussi, L Montagnier, TJ Spira, J Kaplan, D Fishbein, HW Jaffe, JW Curran, DP Francis, Antibodies to the core protein of lymphadenopathy-associated virus (LAV) in patients with AIDS Science. ,vol. 225, pp. 321- 323 ,(1984) , 10.1126/SCIENCE.6330889
H. Towbin, T. Staehelin, J. Gordon, Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 76, pp. 4350- 4354 ,(1979) , 10.1073/PNAS.76.9.4350
D Klatzmann, F Barre-Sinoussi, M. Nugeyre, C Danquet, E Vilmer, C Griscelli, F Brun-Veziret, C Rouzioux, J. Gluckman, J. Chermann, al. et, Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes Science. ,vol. 225, pp. 59- 63 ,(1984) , 10.1126/SCIENCE.6328660
A. Ellrodt, PH. Le Bras, L. Palazzo, F. Brun-Vezinet, P. Segond, L. Montagnier, F. Barre-Sinoussi, M.T. Nugeyre, F. Rey, C. Rouzioux, R. Caquet, J.C. Chermann, ISOLATION OF HUMAN T-LYMPHOTROPIC RETROVIRUS (LAV) FROM ZAIRIAN MARRIED COUPLE, ONE WITH AIDS, ONE WITH PRODROMES The Lancet. ,vol. 323, pp. 1383- 1385 ,(1984) , 10.1016/S0140-6736(84)91877-4
E. Vilmer, C. Rouzioux, F. Vezinet Brun, A. Fischer, J.C. Chermann, F. Barre-Sinoussi, C. Gazengel, C. Dauguet, P. Manigne, C. Griscelli, L. Montagnier, ISOLATION OF NEW LYMPHOTROPIC RETROVIRUS FROM TWO SIBLINGS WITH HAEMOPHILIA B, ONE WITH AIDS The Lancet. ,vol. 323, pp. 753- 757 ,(1984) , 10.1016/S0140-6736(84)91275-3
John R Seale, Acquired Immune Deficiency Syndrome: UCLA Symposia on Molecular and Cellular Biology, New Series, vol 16. Journal of the Royal Society of Medicine. ,vol. 78, pp. 607- 608 ,(1985) , 10.1177/014107688507800722