Cranberries vs Antibiotics to Prevent Urinary Tract Infections

摘要: Background The increasing prevalence of uropathogens resistant to antimicrobial agents has stimulated interest in cranberries prevent recurrent urinary tract infections (UTIs). Methods In a double-blind, double-dummy noninferiority trial, 221 premenopausal women with UTIs were randomized 12-month prophylaxis use trimethoprim-sulfamethoxazole (TMP-SMX), 480 mg once daily, or cranberry capsules, 500 twice daily. Primary end points the mean number symptomatic over 12 months, proportion patients at least 1 UTI, median time first and development antibiotic resistance indigenous Escherichia coli. Results After UTI was higher than TMP-SMX group (4.0 vs 1.8; P = .02), (78.2% 71.1%). Median 4 months for 8 group. month, group, 23.7% fecal 28.1% asymptomatic bacteriuria E coli isolates resistant, whereas 86.3% 90.5% resistant. Similarly, we found increased rates trimethoprim, amoxicillin, ciprofloxacin these after month discontinuation TMP-SMX, reached baseline levels 3 months. Antibiotic did not increase Cranberries equally well tolerated. Conclusion women, is more effective UTIs, expense emerging resistance. Trial Registration isrctn.org Identifier: ISRCTN50717094