Progenitor Endothelial Cell Dysfunction in Heart Failure: Clinical Implication and Therapeutic Target?
作者： Alexander E Berezin
DOI: 10.4172/2161-1025.1000176
关键词:
摘要: Chronic heart failure (HF) is a leading clinical and public problem affected higher risk of morbidity mortality in different population. There emerging evidence regarding that the epigenetic regulation may have clue pathogenesis HF. Epigenetic modifications including DNA methylation, ATP-dependent chromatin remodeling, histone modifications, microRNA-related mechanisms, involve endothelium reparation injury through mobbing differentiation endothelial progenitor cell (EPCs). Recent studies shown cardiovascular contribute to structure functionality EPCs EPCs’ dysfunction worsening repair. The short commentary represented current available an implication development EPC its importance for use as target HF treatment.
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