Citrus limonoids and their semisynthetic derivatives as antifeedant agents against Spodoptera frugiperda larvae. A structure-activity relationship study.

摘要: The antifeedant activity of Citrus-derived limonoids limonin (1), nomilin (2), and obacunone (3) their semisynthetic derivatives 4-26 was evaluated against a commercially important pest, Spodoptera frugiperda. Simple chemical conversions were carried out on the natural obtained from seeds Citrus limon. These focused functional groups considered to be for biological activity, namely C-7 carbonyl furan ring. In particular, reduction at afforded related alcohols, these acetates, oximes, methoximes prepared. Hydrogenation ring also performed obacunone. known properties are confirmed. Comparison with previously reported data shows that insect species vary in behavioral responses structural modifications. Highly significant (P < 0.01) two (1 3) three (4, 8, 10) observed S.