Unusual mode of protein binding by a cytotoxic π-arene ruthenium(II) piano-stool compound containing an O,S-chelating ligand
作者： Jana Hildebrandt , Helmar Görls , Norman Häfner , Giarita Ferraro , Matthias Dürst
DOI: 10.1039/C6DT02380K
关键词:
摘要: A new pseudo-octahedral π-arene ruthenium(II) piano-stool compound, containing an O,S-bidentate ligand (compound 1) and showing significant cytotoxic activity in vitro, was synthesized characterized. In solution stability interaction with the model protein bovine pancreatic ribonuclease (RNase A) were investigated by using UV-Vis absorption spectroscopy. Its crystal structure that of adduct formed upon reaction RNase obtained X-ray crystallography. The comparison between purified compound 1 fragment bound to reveals unusual mode binding includes exchange alteration coordination sphere geometry.
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