Interaction among humoral and neurogenic mechanisms in ventilation control during exercise.

摘要: The control of ventilation during exercise is analyzed by a mathematical model. It represents significant improvement our previous work, including the effect potassium on peripheral chemoreceptors, fast and slow neurogenic component, more accurate description blood flow control. Moreover, feedforward contributions (potassium neurogenic) have been incorporated within larger model feedback ventilatory central chemoreceptors to O2 CO2 changes, interaction among different mechanisms in moderate (100 W) severe (300 exercise. Results suggest that changes can be mostly ascribed mechanisms, which ensure quite constant levels arterial oxygen pressure, thus avoiding involvement mechanisms. Potassium plays mild role steady-state conditions. However, it may transient phase after onset exercise, allowing faster attainment final level. In agreement with physiological literature, evidences presence three distinct kinetic components V E, ensue from temporal superimposition (sometimes antagonistic sometimes synergistic) several